Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis

M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

A Wollenberg, S Christen‐Zäch, A Taieb… - Journal of the …, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis
is made using evaluated clinical criteria. Disease activity and burden are best measured …

IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation

W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

[HTML][HTML] Pathophysiology of atopic dermatitis: Clinical implications

J Kim, BE Kim, DYM Leung - Allergy and asthma proceedings, 2019 - ncbi.nlm.nih.gov
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic
predisposition, epidermal barrier disruption, and dysregulation of the immune system are …

Update on the pathogenesis and therapy of atopic dermatitis

H Li, Z Zhang, H Zhang, Y Guo, Z Yao - Clinical reviews in allergy & …, 2021 - Springer
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by recurrent
eczematous lesions and intense itch. Although it most often starts in infancy and affects …

Impact of genetic polymorphisms on human immune cell gene expression

BJ Schmiedel, D Singh, A Madrigal… - Cell, 2018 - cell.com
While many genetic variants have been associated with risk for human diseases, how these
variants affect gene expression in various cell types remains largely unknown. To address …

[HTML][HTML] Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

E Guttman-Yassky, R Bissonnette, B Ungar… - Journal of Allergy and …, 2019 - Elsevier
Background Dupilumab is an IL-4 receptor α mAb inhibiting signaling of IL-4 and IL-13, key
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …

[HTML][HTML] The role of IL-22 in intestinal health and disease

ME Keir, T Yi, TT Lu, N Ghilardi - Journal of Experimental Medicine, 2020 - rupress.org
The role of IL-22 in intestinal health and disease | Journal of Experimental Medicine |
Rockefeller University Press Skip to Main Content Advertisement Umbrella Alt Text …

Atopic dermatitis endotypes and implications for targeted therapeutics

T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …