The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and
selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of …

Shorebirds and waterfowls are believed to be the reservoir hosts for influenza viruses,
whereas swine putatively act as mixing vessels. The recent identification of two influenza …

Highlights•Approval of first endonuclease inhibitor for influenza treatment.•Represents a
new class of influenza drug.•Single dose is clinically effective.For the first time in nearly 20 …

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

Conspectus Two-metal-ion-dependent nucleases cleave the phosphodiester bonds of
nucleic acids via the two-metal-ion (2M) mechanism. Several high-resolution X-ray …

Influenza viruses are major human pathogens responsible for respiratory diseases affecting
millions of people worldwide and characterized by high morbidity and significant mortality …

It is generally recognised that novel antiviral drugs, less prone to resistance, would be a
desirable alternative to current drug options in order to be able to treat potentially serious …

Objectives Baloxavir marboxil (formerly S-033188) is a first-in-class, orally available, cap-
dependent endonuclease inhibitor licensed in Japan and the USA for the treatment of …