Tumor infiltrating lymphocytes (TILS) and PD-L1 expression in breast cancer: a review of current evidence and prognostic implications from pathologist's perspective

G Angelico, G Broggi, G Tinnirello, L Puzzo… - Cancers, 2023 - mdpi.com
Simple Summary The aim of our study is to provide a wide perspective on the available
literature data on the immune landscape of breast cancers, focusing on TILs and PD-L1 …

Unveiling the immune microenvironment's role in breast cancer: A glimpse into promising frontiers

A Kotsifaki, N Alevizopoulos, V Dimopoulou… - International Journal of …, 2023 - mdpi.com
Breast cancer (BC), one of the most widespread and devastating diseases affecting women
worldwide, presents a significant public health challenge. This review explores the emerging …

[HTML][HTML] Unleashing NK-and CD8 T cells by combining monalizumab and trastuzumab for metastatic HER2-positive breast cancer: Results of the MIMOSA trial

VCM Geurts, L Voorwerk, S Balduzzi, R Salgado… - The Breast, 2023 - Elsevier
The large majority of patients with HER2-positive metastatic breast cancer (MBC) will
eventually develop resistance to anti-HER2 therapy and die of this disease. Despite …

The immunogram of inflammatory breast cancer

C Valenza, D Trapani, N Fusco, X Wang… - Cancer treatment …, 2023 - Elsevier
Inflammatory breast cancer (IBC) is the most aggressive and fatal clinical presentation of
breast cancer. Despite the term “inflammatory”, based on the clinical presentation, IBC is …

Natural-product-derived adjunctive treatments to conventional therapy and their immunoregulatory activities in triple-negative breast cancer

LLY Kan, BCL Chan, PC Leung, CK Wong - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is an invasive and persistent subtype of breast cancer
that is likely to be resistant to conventional treatments. The rise in immunotherapy has …

[HTML][HTML] Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms

Y Feng, N McGuire, A Walton, S Fox, A Papa… - Journal of Pathology …, 2023 - Elsevier
Metaplastic breast cancer (MpBC) is a rare and aggressive subtype of breast cancer, with
data emerging on prognostic factors and survival prediction. This study aimed to develop …

[HTML][HTML] Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers

M Machiels, R Oulkadi, T Tramm, SR Stecklein… - The Breast, 2023 - Elsevier
Radiation therapy (RT) has long been fundamental for the curative treatment of breast
cancer. While substantial progress has been made in the anatomical and technological …

[HTML][HTML] Implications of tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer: clinical oncologist perspectives

ML Rosa, T Reinert, MM Pauletto, G Sartori… - Translational Breast …, 2024 - ncbi.nlm.nih.gov
Breast cancer (BC) is the most common neoplasm in women worldwide and one of the
leading causes of female death. The triple-negative subtype, characterized by the absence …

Immunotherapy for inflammatory breast cancer: current evidences and future perspectives

C Valenza, D Trapani, G Curigliano - Current Opinion in Oncology, 2023 - journals.lww.com
Because of the limited data from clinical trials, no conclusions about the activity of ICIs in IBC
can be drawn. Ongoing clinical trials are assessing many promising ICI-based combination …

[HTML][HTML] Prognostic value and distribution pattern of tumor infiltrating lymphocytes and their subsets in distant metastases of advanced breast cancer

X Sun, C Wang, Y Mao, Z Zhang, J Cui, X Dong… - Clinical Breast …, 2024 - Elsevier
Background There are significant correlations between the levels of tumor infiltrating
lymphocytes (TILs) and the prognosis of primary breast cancer. While little is known about …