Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome
Y Chen, G Wang, J Chen, C Wang, X Dong… - Endocrine …, 2024 - academic.oup.com
The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …
[HTML][HTML] Role of the NLRP3 inflammasome in gynecological disease
X Zheng, D Zhao, Y Jin, Y Liu, D Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the innate
immune system and is a three-part macromolecular complex comprising the NLRP3 protein …
immune system and is a three-part macromolecular complex comprising the NLRP3 protein …
[HTML][HTML] Potential drug targets for tumors identified through Mendelian randomization analysis
N Song, P Shi, K Cui, L Zeng, Z Wang, W Di, J Li… - Scientific Reports, 2024 - nature.com
According to the latest cancer research data, there are a significant number of new cancer
cases and a substantial mortality rate each year. Although a substantial number of clinical …
cases and a substantial mortality rate each year. Although a substantial number of clinical …
[HTML][HTML] Genetic association of serum lipids and lipid-modifying targets with endometriosis: Trans-ethnic Mendelian-randomization and mediation analysis
H Zhang, Y Fan, H Li, X Feng, D Yue - PloS one, 2024 - journals.plos.org
Background Prior observational research identified dyslipidemia as a risk factor for
endometriosis (EMS) but the causal relationship remains unestablished due to inherent …
endometriosis (EMS) but the causal relationship remains unestablished due to inherent …
Associations between cytokines and the risk of female and male infertility: A two-sample Mendelian randomization analysis
L Zhang, H Li, Z Wu, L Han, J Zhang - Journal of Reproductive Immunology, 2024 - Elsevier
Purpose Observational studies have linked cytokines to the occurrence of female and male
infertility. However, it is not clear how biomarkers of inflammation are causally related to …
infertility. However, it is not clear how biomarkers of inflammation are causally related to …
Role of metabolites in mediating the effect of lipidomes on rheumatoid arthritis
X Cai - 2024 - researchsquare.com
Background Evidence from observational studies and clinical trials suggests that lipidomes
are associated with an increased risk of rheumatoid arthritis (RA). However, considering …
are associated with an increased risk of rheumatoid arthritis (RA). However, considering …