Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

Abstract The National Institute on Aging and the Alzheimer's Association convened three
separate work groups in 2011 and single work groups in 2012 and 2018 to create …

Neurodegenerative disorders, including Alzheimer's disease, are associated with
microgliosis. Microglia have long been considered to have detrimental roles in Alzheimer's …

Objective Triggering receptor expressed on myeloid cells‐2 (TREM2) and progranulin
(PGRN) are critical regulators of microglia activation and can be detected in cerebrospinal …

While immune function is known to play a mechanistic role in Alzheimer's disease (AD),
whether immune proteins in peripheral circulation influence the rate of amyloid-β (Aβ) …

Background: Individuals with specific TREM2 gene variants that encode for a Triggering
Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease …

Mer tyrosine kinase (MerTK) is a receptor tyrosine kinase that mediates non-inflammatory,
homeostatic phagocytosis of diverse types of cellular debris. Highly expressed on the …

The single nucleotide polymorphisms rs35349669 and rs10933431 within Inositol
Polyphosphate-5-Phosphatase D (INPP5D) are strongly associated with Alzheimer's …

In the past years, neuroinflammation has been widely investigated in Alzheimer's disease
(AD). Evidence from animal, in vivo and post-mortem studies has shown that inflammatory …

Abstract Triggering Receptor Expressed on Myeloid Cell 2 (TREM2) plays a crucial role in
the transition of microglia from a state of homeostasis to a state associated with the disease …