Current pharmacotherapy and multi-target approaches for Alzheimer's disease

SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …

Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and …

G Magni, B Riboldi, K Petroni, S Ceruti - Biochemical Pharmacology, 2022 - Elsevier
In recent years, experimental evidence suggested a possible role of the gut microbiota in the
onset and development of several neurodegenerative disorders, such as AD and PD, MS …

Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial

J Viña, J Escudero, M Baquero, M Cebrián… - Alzheimer's Research & …, 2022 - Springer
Background Delaying the transition from minimal cognitive impairment to Alzheimer's
dementia is a major concern in Alzheimer's disease (AD) therapeutics. Pathological signs of …

Alzheimer's disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

D Melchiorri, S Merlo, B Micallef, JJ Borg… - Frontiers in …, 2023 - frontiersin.org
Despite extensive research, no disease-modifying therapeutic option, able to prevent, cure
or halt the progression of Alzheimer's disease [AD], is currently available. AD, a devastating …

Non-enzymatic antioxidants against Alzheimer's disease: prevention, diagnosis and therapy

A Varesi, LIM Campagnoli, A Carrara, I Pola, E Floris… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and cognitive decline. Although substantial research has been conducted to …

Regulation of the Notch signaling pathway by natural products for cancer therapy

J Cai, Y Qiao, L Chen, Y Lu, D Zheng - The Journal of Nutritional …, 2023 - Elsevier
The Notch signaling pathway is an evolutionarily conserved pathway that modulates normal
biological processes involved in cellular differentiation, apoptosis, and stem cell self …

Flavonoids as potential antiviral agents for porcine viruses

X Zhang, S Chen, X Li, L Zhang, L Ren - Pharmaceutics, 2022 - mdpi.com
Flavonoids are types of natural substances with phenolic structures isolated from a variety of
plants. Flavonoids have antioxidant, anti-inflammatory, anticancer, and antiviral activities …

[HTML][HTML] ESR1 dysfunction triggers neuroinflammation as a critical upstream causative factor of the Alzheimer's disease process

J Liu, S Yuan, X Niu, R Kelleher, H Sheridan - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) accounts for approximately 60% of dementia cases worldwide.
Advanced age is the most significant risk factor for AD and approximately two-thirds of cases …

Genistein restricts the epithelial mesenchymal transformation (EMT) and stemness of hepatocellular carcinoma via upregulating miR-1275 to inhibit the EIF5A2/PI3K …

X Yang, W Jiang, X Kong, X Zhou, D Zhu, L Kong - Biology, 2022 - mdpi.com
Simple Summary Genistein is a natural phytoestrogen with various antitumor effects. Our
study focused on exploring the mechanisms of microRNAs and genistein to inhibit the …

Insights into prevention mechanisms of bioactive components from healthy diets against Alzheimer's disease

J Wang, Z Yu, Y Peng, B Xu - The Journal of Nutritional Biochemistry, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease in which senile
plaques, neurofibrillary tangles, insulin resistance, oxidative stress, chronic …