Background Crohn's disease (CD) has an increasing incidence and prevalence worldwide.
It is currently believed that both the onset and progression of the disease are closely related …

Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix
following chronic inflammation, and this replacement of organ tissue with fibrotic tissue …

Despite many progresses have been made in the treatment of inflammatory bowel disease,
especially due to the increasing number of effective therapies, the development of tissue …

Inflammatory bowel diseases (IBDs) are a group of chronic diseases characterized by
recurring periods of exacerbation and remission. Fibrosis of the intestine is one of the most …

In inflammatory bowel disease (IBD), chronic inflammation in the gastrointestinal tract can
lead to tissue damage and remodelling, which can ultimately result in fibrosis. Prolonged …

Abstract Background and Aims Endoscopic activity is associated with an increased risk of
surgery in patients with ulcerative colitis [UC]. Transmural activity, as defined by Milan …

Background Fibrosis and inflammation are major pathological changes of Crohn's disease
(CD). Early detection and accurate severity evaluation of CD are critical for patient's …

Intestinal fibrosis is a prevalent complication of Crohn's disease (CD), characterized by
excessive deposition of extracellular matrix (ECM), and no approved drugs are currently …

MicroRNAs (miRNAs) are a group of non-coding RNAs that play a critical role in regulating
epigenetic mechanisms in inflammation-related diseases. Inflammatory bowel diseases …

Background: Intestinal fibrosis in Crohn's disease (CD) is considered to be irreversible and
induces persistent luminal narrowing and strictures. In the past decades, substantial …