The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

SARS-CoV-2 inactivated vaccines have shown remarkable efficacy in clinical trials,
especially in reducing severe illness and casualty. However, the waning of humoral …

Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic. With the continuous …

Antibody responses to SARS-CoV-2 vaccines vary for reasons that remain poorly
understood. A range of sociodemographic, behavioural, clinical, pharmacologic and …

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a global crisis with unprecedented challenges for public health …

The effectiveness of a 3rd dose of SARS-CoV-2 vaccines waned quickly in the Omicron-
predominant period. In response to fast-waning immunity and the threat of Omicron variant …

BACKGROUND Circadian rhythms are evident in basic immune processes, but it is unclear
if rhythms exist in clinical endpoints like vaccine protection. Here, we examined associations …

The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and
adapt to daily changes in the environment. Synchronized to the light–dark cycle with a …