Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa Using DNA-Encoded Small Molecule Library Screening

JS Valastyan, MR Tota, IR Taylor… - ACS chemical …, 2019 - ACS Publications
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections in the United
States. PqsE, a thioesterase enzyme, is vital for virulence of P. aeruginosa, making PqsE an …

Comparative Genomics of Pseudomonas aeruginosa Strains Isolated from Different Ecological Niches

J Gómez-Martínez, RC Rocha-Gracia, E Bello-López… - Antibiotics, 2023 - mdpi.com
The Pseudomonas aeruginosa genome can change to adapt to different ecological niches.
We compared four genomes from a Mexican hospital and 59 genomes from GenBank from …

Pseudomonas Acts as a Reservoir of Novel Tigecycline Resistance Efflux Pump tmexC6D6-toprJ1b and tmexCD-toprJ Variants

CZ Wang, X Gao, XH Liang, LC Lv, LT Lu… - Microbiology …, 2023 - Am Soc Microbiol
Several variants of the plasmid-carried tigecycline resistance gene cluster, tmexCD-toprJ,
have been identified. This study characterized another novel variant, tmexC6D6-toprJ1b …

Aminoglycoside resistance in Pseudomonas aeruginosa: the contribution of the MexXY-OprM efflux pump varies between isolates

A Thacharodi, IL Lamont - Journal of Medical …, 2022 - microbiologyresearch.org
Introduction. Aminoglycoside antibiotics are widely used to treat infections of Pseudomonas
aeruginosa. The MexXY-OprM efflux pump is an important contributor to aminoglycoside …

Reprogramming of antibiotics to combat antimicrobial resistance

KK Dubey, Indu, M Sharma - Archiv der Pharmazie, 2020 - Wiley Online Library
This review outlines a literature‐based approach with illustrative examples of drug
repurposing (one molecule, multiple targets), which will be useful in tackling the problem of …

Genetic and biochemical characterization of BIM-1, a novel acquired subgroup B1 MBL found in a Pseudomonas sp. strain from the Brazilian Amazon region

CO Souza, R Cayô, KVB Lima… - Journal of …, 2023 - academic.oup.com
Objectives To characterize a novel acquired MBL, BIM-1, in a Pseudomonas# 2 (subgroup
P. guariconensis) strain isolated from the Aurá river located in the Brazilian Amazon …

The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3(48-56) Against Pseudomonas aeruginosa With No Detectable Resistance

D Zhu, F Chen, YC Chen, H Peng… - Frontiers in Cellular and …, 2021 - frontiersin.org
The emergence of multidrug-resistant (MDR) pathogens has become a global public health
crisis. Among them, MDR Pseudomonas aeruginosa is the main cause of nosocomial …

Novel Chromosome-Borne Accessory Genetic Elements Carrying Multiple Antibiotic Resistance Genes in Pseudomonas aeruginosa

T Yu, H Yang, J Li, F Chen, L Hu, Y Jing… - Frontiers in Cellular …, 2021 - frontiersin.org
Pseudomonas aeruginosa is noted for its intrinsic antibiotic resistance and capacity of
acquiring additional resistance genes. In this study, the genomes of nine clinical P …

Comprehensive genome data analysis establishes a triple whammy of carbapenemases, ICEs and multiple clinically relevant bacteria

J Botelho, J Mourão, AP Roberts… - Microbial …, 2020 - microbiologyresearch.org
Carbapenemases inactivate most β-lactam antibiotics, including carbapenems, and have
frequently been reported among Enterobacteriaceae, Acinetobacter spp. and Pseudomonas …

Lethal weapon IL: A nano-copper/tetraalkylphosphonium ionic liquid composite material with potent antibacterial activity

A Banerjee, BR Aremu, S Dehghandokht… - RSC …, 2023 - pubs.rsc.org
Ionic liquid (IL) based composite materials have shown great promise as antimicrobial
agents, owing to their inherent germicidal properties, as well as their ability to stabilize metal …