The Hierarchical Taxonomy of Psychopathology (HiTOP) has emerged out of the
quantitative approach to psychiatric nosology. This approach identifies psychopathology …

Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …

Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta …

Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Personality and cognitive function are heritable mental traits whose genetic foundations may
be distributed across interconnected brain functions. Previous studies have typically treated …

Binge eating disorder (BED) is the most common eating disorder, yet its genetic architecture
remains largely unknown. Studying BED is challenging because it is often comorbid with …

The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …

Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …

Substance use disorders commonly co-occur with one another and with other psychiatric
disorders. They share common features including high impulsivity, negative affect, and lower …