Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review

PG Djupesland - Drug delivery and translational research, 2013 - Springer
Nasal delivery is the logical choice for topical treatment of local diseases in the nose and
paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also …

The nasal approach to delivering treatment for brain diseases: an anatomic, physiologic, and delivery technology overview

PG Djupesland, JC Messina, RA Mahmoud - Therapeutic delivery, 2014 - Taylor & Francis
The intricate pathophysiology of brain disorders, difficult access to the brain, and the
complexity and high risks and costs of drug development represent major hurdles for …

Computational characterization of inhaled droplet transport to the nasopharynx

S Basu - Scientific Reports, 2021 - nature.com
How human respiratory physiology and the transport phenomena associated with inhaled
airflow in the upper airway proceed to impact transmission of SARS-CoV-2, leading to the …

[图书][B] Multiphase flow handbook

E Michaelides, CT Crowe, JD Schwarzkopf - 2016 - books.google.com
The Multiphase Flow Handbook, Second Edition is a thoroughly updated and reorganized
revision of the late Clayton Crowe's work, and provides a detailed look at the basic concepts …

[图书][B] Computational fluid and particle dynamics in the human respiratory system

J Tu, K Inthavong, G Ahmadi - 2012 - books.google.com
Traditional research methodologies in the human respiratory system have always been
challenging due to their invasive nature. Recent advances in medical imaging and …

Mechanics of airflow in the human nasal airways

DJ Doorly, DJ Taylor, RC Schroter - Respiratory physiology & neurobiology, 2008 - Elsevier
The mechanics of airflow in the human nasal airways is reviewed, drawing on the findings of
experimental and computational model studies. Modelling inevitably requires simplifications …

[HTML][HTML] Simulation-based approaches for drug delivery systems: navigating advancements, opportunities, and challenges

I Salahshoori, M Golriz, MAL Nobre, S Mahdavi… - Journal of Molecular …, 2023 - Elsevier
Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

L Salade, N Wauthoz, J Goole, K Amighi - International journal of …, 2019 - Elsevier
Nasal delivery offers many benefits over other conventional routes of delivery (eg oral or
intravenous administration). Benefits include, among others, a fast onset of action, non …

Effects of surface smoothness on inertial particle deposition in human nasal models

JD Schroeter, GJM Garcia, JS Kimbell - Journal of aerosol science, 2011 - Elsevier
Computational fluid dynamics (CFD) predictions of inertial particle deposition have not
compared well with data from nasal replicas due to effects of surface texture and the …

Detailed micro-particle deposition patterns in the human nasal cavity influenced by the breathing zone

YD Shang, K Inthavong, JY Tu - Computers & Fluids, 2015 - Elsevier
The breathing region connects the nasal cavity with the outside environmental air where
flow is accelerated through the nostrils. Particles introduced into the nasal cavity without …