pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway

Q Zong, Y Pan, Y Liu, Z Wu, Z Huang, Y Zhang… - International …, 2023 - Elsevier
Neuroinflammation is closely related to the etiology and progression of neurodegenerative
diseases such as Parkinson disease and Alzheimer disease. pNaktide, an Src inhibitor …

Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS‐CoV‐2?

MR Khezri, M Ghasemnejad‐Berenji… - Journal of Food …, 2022 - Wiley Online Library
Hesperetin, mainly found in citrus honey, has antioxidant, anti‐inflammatory, and antiviral
properties. Recently, the effect of hesperetin on different aspects of SARS‐CoV‐2 infection …

[HTML][HTML] Lipid nanoparticle encapsulated oleic acid induced lipotoxicity to hepatocytes via ROS overload and the DDIT3/BCL2/BAX/Caspases signaling in vitro and in …

YN Liu, HX Zhu, TY Li, X Yang, XJ Li… - Free Radical Biology and …, 2024 - Elsevier
Abstract Background To date, Non-alcoholic fatty liver disease (NAFLD) is one of the most
common liver disease associated with clinical complications. Dietary fatty acids have been …

7‐Hydroxyflavone improves nonalcoholic fatty liver disease by acting on STK24

X Qi, Y Zhang, Q Liao, Y Xiao, T Jiang… - Phytotherapy …, 2024 - Wiley Online Library
The escalating incidence of nonalcoholic fatty liver disease (NAFLD) is closely associated
with a high‐fat diet, leading to a decline in quality of life and significant health impairment. 7 …

Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosis

B Zhao, K Liu, X Liu, Q Li, Z Li, J Xi… - Phytotherapy …, 2024 - Wiley Online Library
Liver fibrosis is a dynamic pathological process that can be triggered by any chronic liver
injury. If left unaddressed, it will inevitably progress to the severe outcomes of liver cirrhosis …

Keap1-Nrf2/ARE pathway-based investigation into the mechanism of edaravone dexborneol in cerebral infarction model neuroprotection

X Yang, B Wang, Y Wang - Cellular and Molecular Biology, 2022 - cellmolbiol.org
The neuroprotection of acute cerebral infarction (ACI) model by edaravone dexborneol (ED)-
mediated Keap1-Nrf2/ARE signal pathway was investigated. Sham operation was set as a …

Caenorhabditis elegans as a Model for the Effects of Phytochemicals on Mitochondria and Aging

F Schmitt, GP Eckert - Biomolecules, 2022 - mdpi.com
The study of aging is an important topic in contemporary research. Considering the
demographic changes and the resulting shifts towards an older population, it is of great …

Pharmacologic Comparison of High-Dose Hesperetin and Quercetin on MDCK II Cell Viability, Tight Junction Integrity, and Cell Shape

M Nakashima, N Goda, T Tenno, A Kotake, Y Inotsume… - Antioxidants, 2023 - mdpi.com
The modulation of tight junction (TJ) integrity with small molecules is important for drug
delivery. High-dose baicalin (BLI), baicalein (BLE), quercetin (QUE), and hesperetin (HST) …

Proteomics reveals the pharmacological mechanism of flavonoids from Astragali Complanati Semen in preventing chronic liver injury

L Chen, X Kong, R Zhou, J Hu, R Zhou, Z Song, Z Tang… - Phytomedicine, 2024 - Elsevier
ABSTRACT Background Total flavonoids from Astragali Complanati Semen (TFACS), the
main active ingredients in Astragali Complanati Semen (ACS), have been shown to have a …

Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death

T Zhang, C Wang, A Song, X Lei, G Li, H Sun… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance When left untreated, liver fibrosis (LF) causes various
chronic liver diseases. Earthworms (Pheretima aspergillum) are widely used in traditional …