Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …

Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Fluorouracil (5-FU) is an essential component of systemic chemotherapy for colorectal
cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Traditional chemotherapy is being considered due to hindrances caused by systemic
toxicity. Currently, the administration of multiple chemotherapeutic drugs with different …

With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …