[HTML][HTML] Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs
EL Sternburg, JA Estep, DK Nguyen, Y Li… - Scientific reports, 2018 - nature.com
Approximately 1500 RNA-binding proteins (RBPs) profoundly impact mammalian cellular
function by controlling distinct sets of transcripts, often using sequence-specific binding to …
function by controlling distinct sets of transcripts, often using sequence-specific binding to …
Modulation and function of Pumilio proteins in cancer
ILZ Silva, AA Kohata, P Shigunov - Seminars in cancer biology, 2022 - Elsevier
Post-transcriptional regulation is involved in tumorigenesis, and in this control, RNA-binding
proteins are the main protagonists. Pumilio proteins are highly conserved RNA-binding …
proteins are the main protagonists. Pumilio proteins are highly conserved RNA-binding …
Noncoding RNAs in cancer development
CP Lin, L He - Annual review of cancer biology, 2017 - annualreviews.org
It is becoming increasingly clear that a large repertoire of noncoding RNAs (ncRNAs) are
actively transcribed from the mammalian genome, regulating diverse cellular processes in …
actively transcribed from the mammalian genome, regulating diverse cellular processes in …
Understanding and engineering RNA sequence specificity of PUF proteins
G Lu, SJ Dolgner, TMT Hall - Current opinion in structural biology, 2009 - Elsevier
PUF proteins are RNA-binding proteins named for founding members PUMILIO and fem-3
binding factor (FBF). Together these proteins represent the range of known RNA recognition …
binding factor (FBF). Together these proteins represent the range of known RNA recognition …
Post-transcriptional control of gene expression during mouse oogenesis
HJ Clarke - Mouse Development: From Oocyte to Stem Cells, 2012 - Springer
Post-transcriptional mechanisms play a central role in regulating gene expression during
oogenesis and early embryogenesis. Growing oocytes accumulate an enormous quantity of …
oogenesis and early embryogenesis. Growing oocytes accumulate an enormous quantity of …
Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals
J Fang, C Pietzsch, H Witwit… - Proceedings of the …, 2022 - National Acad Sciences
Completion of the Lassa virus (LASV) life cycle critically depends on the activities of the
virally encoded, RNA-dependent RNA polymerase in replication and transcription of the viral …
virally encoded, RNA-dependent RNA polymerase in replication and transcription of the viral …
[HTML][HTML] Expanding the binding specificity for RNA recognition by a PUF domain
W Zhou, D Melamed, G Banyai, C Meyer… - Nature …, 2021 - nature.com
The ability to design a protein to bind specifically to a target RNA enables numerous
applications, with the modular architecture of the PUF domain lending itself to new RNA …
applications, with the modular architecture of the PUF domain lending itself to new RNA …
[HTML][HTML] A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity
In the Caenorhabditis elegans germline, fem-3 Binding Factor (FBF) partners with LST-1 to
maintain stem cells. A crystal structure of an FBF-2/LST-1/RNA complex revealed that FBF-2 …
maintain stem cells. A crystal structure of an FBF-2/LST-1/RNA complex revealed that FBF-2 …
[HTML][HTML] Role of PUM RNA-binding proteins in cancer
Simple Summary PUM1 and PUM2 are RNA-binding Pumilio proteins controlling the
accessibility of hundreds of mRNAs for translation in a variety of human tissues. As a result …
accessibility of hundreds of mRNAs for translation in a variety of human tissues. As a result …
Architecture and dynamics of overlapped RNA regulatory networks
A single protein can bind and regulate many mRNAs. Multiple proteins with similar
specificities often bind and control overlapping sets of mRNAs. Yet little is known about the …
specificities often bind and control overlapping sets of mRNAs. Yet little is known about the …