Diabetes, diabetic complications, and fracture risk

L Oei, F Rivadeneira, MC Zillikens, EHG Oei - Current osteoporosis reports, 2015 - Springer
Diabetes and osteoporosis are both common diseases with increasing prevalences in the
aging population. There is increasing evidence corroborating an association between …

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

J Morrison, N Knoblauch, JH Marcus, M Stephens… - Nature …, 2020 - nature.com
Mendelian randomization (MR) is a valuable tool for detecting causal effects by using
genetic variant associations. Opportunities to apply MR are growing rapidly with the …

Bone damage in type 2 diabetes mellitus

V Carnevale, E Romagnoli, L D'Erasmo… - Nutrition, Metabolism and …, 2014 - Elsevier
This review focuses on the mechanisms determining bone fragility in patients with type 2
diabetes mellitus (T2DM). Despite bone mineral density (BMD) is usually normal or more …

Adipose mesenchymal stem cells‐secreted extracellular vesicles containing microRNA‐192 delays diabetic retinopathy by targeting ITGA1

C Gu, H Zhang, Y Gao - Journal of cellular physiology, 2021 - Wiley Online Library
Diabetic retinopathy (DR) has characteristics of early loss of capillary pericytes, contributing
to aberrant endothelial proliferation and angiogenesis. The function of extracellular vesicles …

A regulatory variant at 3q21. 1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

N Sinnott-Armstrong, IS Sousa, S Laber… - Cell Metabolism, 2021 - cell.com
Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain
largely unknown. To identify genetic loci that may have pleiotropic effects, we studied …

A Mendelian randomization study of the effect of type‐2 diabetes and glycemic traits on bone mineral density

OS Ahmad, A Leong, JA Miller, JA Morris… - Journal of Bone and …, 2017 - academic.oup.com
ABSTRACT Type‐2 diabetes (T2D) is associated in observational studies with both higher
bone mineral density (BMD) and higher fracture risk for given BMD. These relationships may …

Glucagon‐like peptide‐1 (GLP‐1) receptor agonists: potential to reduce fracture risk in diabetic patients?

G Luo, H Liu, H Lu - British journal of clinical pharmacology, 2016 - Wiley Online Library
This review summarizes current knowledge about glucagon‐like peptide 1 receptor agonists
(GLP‐1 RA) and their effects on bone metabolism and fracture risk. Recent in vivo and in …

Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes

J Lee, K Han, SH Park, MK Kim, DJ Lim, KH Yoon… - Metabolism, 2022 - Elsevier
Background Diabetes is associated with a high risk of fragility fracture. However, there are
controversies regarding the effect of fluctuations in metabolic parameters on the risk of …

TMT-based quantitative proteomics reveals cochlear protein profile alterations in mice with noise-induced hearing loss

L Miao, J Zhang, L Yin, Y Pu - International Journal of Environmental …, 2021 - mdpi.com
Noise-induced hearing loss (NIHL) is a global occupational disease affecting health. To
date, genetic polymorphism studies on NIHL have been performed extensively. However …

Association between trajectories of fasting plasma glucose and risk of osteoporosis in non-diabetic and diabetic populations

P Wang, Y Zhang, R Shan, J Wu, S Man… - Frontiers in Public …, 2022 - frontiersin.org
Introduction Previous studies based on a single measure of fasting plasma glucose (FPG)
showed an inconsistent conclusion about the association between FPG and osteoporosis …