To understand the genetics of type 2 diabetes in people of Japanese ancestry, we
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …

Complex traits and common diseases are extremely polygenic, their heritability spread
across thousands of loci. One possible explanation is that thousands of genes and loci have …

Prospective observational studies support the use of long-chain omega-3 polyunsaturated
fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, placing an increasing burden on human health. NAFLD is a complex …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals …

The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and
heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data …

Diabetes has reached epidemic proportions worldwide. Currently, approximately 537 million
adults (20–79 years) have diabetes, and the total number of people with diabetes is …

The difficulty in finding causative mutations has hampered their use in genomic prediction.
Here, we present a methodology to fine-map potentially causal variants genome-wide by …

Exercise induces signaling networks to improve muscle function and confer health benefits.
To identify divergent and common signaling networks during and after different exercise …

Modern high-throughput experiments provide a rich resource to investigate causal
determinants of disease risk. Mendelian randomization (MR) is the use of genetic variants as …