Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …

Droplet-based single-cell assays, including single-cell RNA sequencing (scRNA-seq),
single-nucleus RNA sequencing (snRNA-seq) and cellular indexing of transcriptomes and …

Aging is a major risk factor contributing to pathophysiological changes in the heart, yet its
intrinsic mechanisms have been largely unexplored in primates. In this study, we …

COVID-19 is linked to endotheliopathy and coagulopathy, which can result in multi-organ
failure. The mechanisms causing endothelial damage due to severe acute respiratory …

The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …

Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia, and
increases the risk of many aging-related metabolic diseases. Here, we report phenotypic …