During immune responses, activating ligands would trigger dynamic spatiotemporal
organization of immunoreceptors at the cell interface, governing the fate and effector …

DNA and RNA nanostructures are being investigated as therapeutics, vaccines, and drug
delivery systems. These nanostructures can be functionalized with guests ranging from …

Wireframe DNA origami can be used to fabricate virus-like particles for a range of
biomedical applications, including the delivery of nucleic acid therapeutics. However, the …

Mosaic nanoparticle vaccines with heterotypic antigens exhibit broad‐spectrum antiviral
capabilities, but the impact of antigen proportions and distribution patterns on vaccine …

Fibrous nanomaterials containing silica, titanium oxide, and carbon nanotubes are
notoriously known for their undesirable inflammatory responses and associated toxicities …

Immunogen design approaches aim to control the specificity and quality of antibody
responses elicited by next-generation vaccines. Here, we use computational protein design …

Nucleic acid nanoparticles (NANPs) are increasingly used in preclinical investigations as
delivery vectors. Tools that can characterize assembly and assess quality will accelerate …

Biochemical reactions are essential biological processes of living systems, which are also
significant in many fields, such as biomedicine, cytobiology, synthetic biology, and chemical …

Structure-guided rational immunogen design can generate optimized immunogens that elicit
a desired humoral response. Design strategies often center on targeting conserved sites on …

B cells are the cornerstone of our body's defense system, producing precise antibodies and
safeguarding immunological memory for future protection against pathogens. While we have …