The kaleidoscope of microglial phenotypes

ML Dubbelaar, L Kracht, BJL Eggen… - Frontiers in …, 2018 - frontiersin.org
Gene expression analyses of microglia, the tissue-resident macrophages of the central
nervous system (CNS), led to the identification of homeostatic as well as neurological …

Effects of neurotrophic factors in glial cells in the central nervous system: expression and properties in neurodegeneration and injury

S Pöyhönen, S Er, A Domanskyi… - Frontiers in physiology, 2019 - frontiersin.org
Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

Microenvironmental regulation of tumor progression and therapeutic response in brain metastasis

M Schulz, A Salamero-Boix, K Niesel… - Frontiers in …, 2019 - frontiersin.org
Cellular and non-cellular components of the tumor microenvironment (TME) are emerging
as key regulators of primary tumor progression, organ-specific metastasis, and therapeutic …

Cell-type-specific epigenetic effects of early life stress on the brain

MF Rahman, PO McGowan - Translational Psychiatry, 2022 - nature.com
Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased
vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA …

The many faces of astrocytes in Alzheimer's disease

MD Monterey, H Wei, X Wu, JQ Wu - Frontiers in Neurology, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease and is the most
common cause of dementia in an aging population. The majority of research effort has …

The evolution of single-cell RNA sequencing technology and application: progress and perspectives

S Wang, ST Sun, XY Zhang, HR Ding, Y Yuan… - International Journal of …, 2023 - mdpi.com
As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

Dissemination of brain inflammation in traumatic brain injury

K Shi, J Zhang, J Dong, FD Shi - Cellular & molecular immunology, 2019 - nature.com
Traumatic brain injury (TBI) is recognized as a global health problem due to its increasing
occurrence, challenging treatment, and persistent impacts on brain pathophysiology. Neural …

The in vivo endothelial cell translatome is highly heterogeneous across vascular beds

ACA Cleuren, MA van der Ent… - Proceedings of the …, 2019 - National Acad Sciences
Endothelial cells (ECs) are highly specialized across vascular beds. However, given their
interspersed anatomic distribution, comprehensive characterization of the molecular basis …

Single-cell and single-nuclei RNA sequencing as powerful tools to decipher cellular heterogeneity and dysregulation in neurodegenerative diseases

R Cuevas-Diaz Duran, JC González-Orozco… - Frontiers in Cell and …, 2022 - frontiersin.org
Neurodegenerative diseases affect millions of people worldwide and there are currently no
cures. Two types of common neurodegenerative diseases are Alzheimer's (AD) and …

Microglial NLRP3 inflammasome activation in multiple sclerosis

M Olcum, B Tastan, C Kiser, S Genc, K Genc - Advances in protein …, 2020 - Elsevier
Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …