[HTML][HTML] STAT1 and its crucial role in the control of viral infections

M Tolomeo, A Cavalli, A Cascio - International Journal of Molecular …, 2022 - mdpi.com
The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the
immune response against viruses and other pathogens by transducing, in the nucleus, the …

Potential convergence of olfactory dysfunction in Parkinson's disease and COVID-19: The role of neuroinflammation

H Li, J Qian, Y Wang, J Wang, X Mi, L Qu… - Ageing Research …, 2024 - Elsevier
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that affects 7-10 million
individuals worldwide. A common early symptom of PD is olfactory dysfunction (OD), and …

[HTML][HTML] Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection

DJ Kenney, AK O'Connell, J Turcinovic, P Montanaro… - Cell reports, 2022 - cell.com
The human immunological mechanisms defining the clinical outcome of SARS-CoV-2
infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate …

[HTML][HTML] Exploration of Fuzheng Yugan Mixture on COVID-19 based on network pharmacology and molecular docking

X Jiang, J Zhou, Z Yu, X Gu, Y Lu, Y Ruan, T Wang - Medicine, 2023 - journals.lww.com
Abstract After the World Health Organization declared coronavirus disease 2019 (COVID-
19), as a global pandemic, global health workers have been facing an unprecedented and …

[HTML][HTML] COVID-19Base v3: Update of the knowledgebase for drugs and biomedical entities linked to COVID-19

SA Basit, R Qureshi, S Musleh, R Guler… - Frontiers in Public …, 2023 - frontiersin.org
COVID-19 has taken a huge toll on our lives over the last 3 years. Global initiatives put
forward by all stakeholders are still in place to combat this pandemic and help us learn …

[HTML][HTML] Double-edged sword of JAK/STAT signaling pathway in viral infections: novel insights into virotherapy

M Mahjoor, G Mahmoudvand, S Farokhi… - Cell Communication and …, 2023 - Springer
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate
signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other …

Plasmablast‐like Phenotype Among Antigen‐Experienced CXCR5–CD19low B Cells in Systemic Lupus Erythematosus

F Szelinski, AL Stefanski… - Arthritis & …, 2022 - Wiley Online Library
Objective Altered composition of the B cell compartment in the pathogenesis of systemic
lupus erythematosus (SLE) is characterized by expanded plasmablast and IgD–CD27 …

[HTML][HTML] Myeloid CD169/Siglec1: An immunoregulatory biomarker in viral disease

S Herzog, PC Fragkou, BM Arneth, S Mkhlof… - Frontiers in …, 2022 - frontiersin.org
CD169, also known as Siglec1 or Sialoadhesin (Sn), is a surface adhesion molecule on
human myeloid cells. Being part of the Siglec family, it acts as a receptor for sialylated …

[HTML][HTML] Dysregulated interferon response and immune hyperactivation in severe COVID-19: targeting STATs as a novel therapeutic strategy

M Eskandarian Boroujeni, A Sekrecka… - Frontiers in …, 2022 - frontiersin.org
A disease outbreak in December 2019, caused by a novel coronavirus SARS-CoV-2, was
named COVID-19. SARS-CoV-2 infects cells from the upper and lower respiratory tract …

[HTML][HTML] The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling

MI Goncheva, RM Gibson, AC Shouldice, JD Dikeakos… - iScience, 2023 - cell.com
Summary The Severe Acute Respiratory Syndrome Coronavirus 2 (CoV-2) pandemic has
affected millions globally. A significant complication of CoV-2 infection is secondary bacterial …