Evolutionary theory holds that aging is a consequence of the declining force of natural
selection with age. We discuss here the evidence that among the causes of aging in …

Cellular senescence suppresses cancer by arresting cell proliferation, essentially
permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the …

Abstract Cyclin‐dependent kinase 5 (Cdk5) is recognized as an essential molecule in the
brain, where it regulates several neuronal activities, including cytoskeletal remodeling and …

Progeria is a human disease model of accelerated ageing. 1–3 The progeria syndrome is a
rare genetic disorder, first reported in 1886 by Hutchinson and Guilford in England. 4 The …

In recent years data on cancer incidence in the USA, the Netherlands, and in Hong Kong
indicate a flattening and perhaps a turnover at advanced age, but no model has been …

This paper links ageism to the anti-ageing culture embedded in biological science. It
presents two simple ideal types of the relationship of culture and science and uses these to …

High extracellular NaCl was previously shown to increase the number of DNA breaks in
mammalian cells in tissue culture, renal medullary cells in vivo, C. elegans, and marine …

We have investigated whether the average relative telomere length of lens epithelial cells
(LECs) from brown Norway rats decreases with the age of the donor animal, and whether …

Senescence and apoptosis constitute types of cellular responses that normally ensure
homeostasis, when endogenous or exogenous signals occur. Their deregulation is often …

This paper provides both an overview of and a personal perspective on the field of 'anti-
ageing'. In the late 20th century, progress in the science of ageing re-invigorated activity …