Biofilm antimicrobial susceptibility testing: where are we and where could we be going?

T Coenye - Clinical microbiology reviews, 2023 - Am Soc Microbiol
Our knowledge about the fundamental aspects of biofilm biology, including the mechanisms
behind the reduced antimicrobial susceptibility of biofilms, has increased drastically over the …

DeepDDS: deep graph neural network with attention mechanism to predict synergistic drug combinations

J Wang, X Liu, S Shen, L Deng… - Briefings in …, 2022 - academic.oup.com
Motivation Drug combination therapy has become an increasingly promising method in the
treatment of cancer. However, the number of possible drug combinations is so huge that it is …

Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

N Morales-Durán, A León-Buitimea… - Heliyon, 2024 - cell.com
Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are
the main drivers in developing drug-resistant bacteria. The emergence of the rapid global …

Combinatorial screening SlipChip for rapid phenotypic antimicrobial susceptibility testing

X Li, X Liu, Z Yu, Y Luo, Q Hu, Z Xu, J Dai, N Wu… - Lab on a Chip, 2022 - pubs.rsc.org
Antimicrobial resistance (AMR) by bacteria is a serious global threat, and a rapid, high-
throughput, and easy-to-use phenotypic antimicrobial susceptibility testing (AST) method is …

Overview of antimicrobial resistance: an emerging silent pandemic

M Paneri, P Sevta - Global Journal of Medical, Pharmaceutical, and …, 2023 - gjmpbu.org
Before the outbreak of Coronavirus disease-19, one of the top 10 most risks identified by the
World Health Organization (WHO) is antimicrobial resistance (AMR) that is also known as …

Omadacycline Potentiates Clarithromycin Activity Against Mycobacterium abscessus

BT Bich Hanh, NT Quang, Y Park, BE Heo… - Frontiers in …, 2021 - frontiersin.org
Mycobacterium abscessus is a difficult respiratory pathogen to treat, when compared to
other nontuberculus mycobacteria (NTM), due to its drug resistance. In this study, we aimed …

Isothermal microcalorimetry improves accuracy and time to bacterial detection of periprosthetic joint infection after total joint arthroplasty

KH Cichos, RJ Ruark, ES Ghanem - Journal of Clinical …, 2023 - Am Soc Microbiol
Isothermal microcalorimetry (IMC) was evaluated compared to conventional cultures to
determine the clinical performance for diagnosing periprosthetic joint infection (PJI) of …

Advances in pulmonary drug delivery targeting microbial biofilms in respiratory diseases

A Sharma, D Kumar, K Dahiya, S Hawthorne… - …, 2021 - Taylor & Francis
The increasing burden of respiratory diseases caused by microbial infections poses an
immense threat to global health. This review focuses on the various types of biofilms that …

The quorum-sensing inhibitor furanone C-30 rapidly loses its tobramycin-potentiating activity against Pseudomonas aeruginosa biofilms during experimental evolution

M Bové, X Bao, A Sass, A Crabbé… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The use of quorum-sensing inhibitors (QSI) has been proposed as an alternative strategy to
combat antibiotic resistance. QSI reduce the virulence of a pathogen without killing it and it is …

Isothermal microcalorimetry vs checkerboard assay to evaluate in-vitro synergism of meropenem–amikacin and meropenem–colistin combinations against multi-drug …

A Antonelli, M Coppi, C Tellapragada, B Hasan… - International Journal of …, 2022 - Elsevier
Objectives To evaluate the activity of meropenem–amikacin and meropenem–colistin
combinations with checkerboard broth microdilution (CKBM) compared with isothermal …