Cellular interactions in the pathogenesis of interstitial lung diseases

G Bagnato, S Harari - European Respiratory Review, 2015 - Eur Respiratory Soc
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …

[HTML][HTML] Molecular and cellular mechanisms of pulmonary fibrosis

NW Todd, IG Luzina, SP Atamas - Fibrogenesis & tissue repair, 2012 - Springer
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

[HTML][HTML] Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization

TH Lee, CF Yeh, YT Lee, YC Shih, YT Chen… - Nature …, 2020 - nature.com
Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options.
There is a clear need to identify novel mediators of PF to develop effective therapeutics …

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

SA Hosseini, F Zahedipour, T Sathyapalan… - …, 2021 - Wiley Online Library
Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of
the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several …

[HTML][HTML] Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary …

Y Zhou, JY Lee, CM Lee, WK Cho, MJ Kang… - Journal of Biological …, 2012 - ASBMB
Dysregulated amphiregulin (AR) expression and EGR receptor (EGFR) activation have been
described in animal models of pulmonary fibrosis and in patients with idiopathic pulmonary …

Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease

B Ng, J Dong, S Viswanathan, AA Widjaja… - The FASEB …, 2020 - Wiley Online Library
Repetitive pulmonary injury causes fibrosis and inflammation that underlies chronic lung
diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for …

[HTML][HTML] Myofibroblasts and lung fibrosis induced by carbon nanotube exposure

J Dong, Q Ma - Particle and fibre toxicology, 2016 - Springer
Carbon nanotubes (CNTs) are newly developed materials with unique properties and a
range of industrial and commercial applications. A rapid expansion in the production of CNT …

[HTML][HTML] MicroRNAs as potential targets for progressive pulmonary fibrosis

S Rajasekaran, P Rajaguru… - Frontiers in …, 2015 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and devastating disorder. It is
characterized by alveolar epithelial cell injury and activation, infiltration of inflammatory cells …

[HTML][HTML] Mesenchymal stem cells correct inappropriate epithelial–mesenchyme relation in pulmonary fibrosis using stanniocalcin-1

M Ono, S Ohkouchi, M Kanehira, N Tode… - Molecular Therapy, 2015 - cell.com
Current hypotheses suggest that aberrant wound healing has a critical role in the
pathogenesis of idiopathic pulmonary fibrosis (IPF). In these hypotheses, continuous TGF-β1 …

Lymphocyte aggregates persist and accumulate in the lungs of patients with idiopathic pulmonary fibrosis

NW Todd, RG Scheraga, JR Galvin… - Journal of …, 2013 - Taylor & Francis
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with no known
effective therapy. It is often assumed, but has not been objectively evaluated, that pulmonary …