Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of
central nervous system (CNS) functionality. It has been shown that neuroinflammation …

Over the last decade, there has been increased interest in the role of the gut microbiome in
health including brain health. This is by no means a new theory; Elie Metchnikoff proposed …

Age-related neurological disorders (ANDs), including neurodegenerative diseases, are
multifactorial disorders with a risk that increases with aging. ANDs are generally …

Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against
the microbiota, as well as a conduit for signaling between the microbiota and systemic host …

The brain is unique and the most complex organ of the body, containing neurons and
several types of glial cells of different origins and properties that protect and ensure normal …

Understanding the role of astrocytes in the central nervous system has changed dramatically
over the last decade. The accumulating findings indicate that glial cells are involved not only …

Abstract Purpose of Review Neuroinflammation plays a significant role in Parkinson's
disease (PD) etiology along with mitochondrial dysfunction and impaired proteostasis. In this …

Aging is characterized by the progressive decline of physiological function and tissue
homeostasis leading to increased vulnerability, degeneration, and death. Aging‐related …

Aging is accompanied by a host of social and biological changes that correlate with
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …