NMDA receptors, place cells and hippocampal spatial memory

K Nakazawa, TJ McHugh, MA Wilson… - Nature Reviews …, 2004 - nature.com
N-methyl-d-aspartate receptors (NMDARs) in the rodent hippocampus have been shown to
be essential for spatial learning and memory, and for the induction of long-term synaptic …

Independent rate and temporal coding in hippocampal pyramidal cells

J Huxter, N Burgess, J O'Keefe - Nature, 2003 - nature.com
In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal
spatial aspects of the animal's environment or behaviour. The temporal code takes the form …

Role of experience and oscillations in transforming a rate code into a temporal code

MR Mehta, AK Lee, MA Wilson - Nature, 2002 - nature.com
In the vast majority of brain areas, the firing rates of neurons, averaged over several hundred
milliseconds to several seconds, can be strongly modulated by, and provide accurate …

Theta returns

MJ Kahana, D Seelig, JR Madsen - Current opinion in neurobiology, 2001 - Elsevier
Recent physiological studies have implicated theta—a high-amplitude 4–8 Hz oscillation
that is prominent in rat hippocampus during locomotion, orienting and other voluntary …

Hippocampus-independent phase precession in entorhinal grid cells

T Hafting, M Fyhn, T Bonnevie, MB Moser, EI Moser - Nature, 2008 - nature.com
Theta-phase precession in hippocampal place cells is one of the best-studied experimental
models of temporal coding in the brain. Theta-phase precession is a change in spike timing …

Impaired tuning of neural ensembles and the pathophysiology of schizophrenia: a translational and computational neuroscience perspective

JH Krystal, A Anticevic, GJ Yang, G Dragoi… - Biological …, 2017 - Elsevier
The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …

[HTML][HTML] Increased prevalence of calcium transients across the dendritic arbor during place field formation

MEJ Sheffield, MD Adoff, DA Dombeck - Neuron, 2017 - cell.com
Hippocampal place cell ensembles form a cognitive map of space during exposure to novel
environments. However, surprisingly little evidence exists to support the idea that synaptic …

Dual phase and rate coding in hippocampal place cells: theoretical significance and relationship to entorhinal grid cells

J O'keefe, N Burgess - Hippocampus, 2005 - Wiley Online Library
We review the ideas and data behind the hypothesis that hippocampal pyramidal cells
encode information by their phase of firing relative to the theta rhythm of the EEG. Particular …

[HTML][HTML] Slow and fast gamma rhythms coordinate different spatial coding modes in hippocampal place cells

KW Bieri, KN Bobbitt, LL Colgin - Neuron, 2014 - cell.com
Previous work has hinted that prospective and retrospective coding modes exist in
hippocampus. Prospective coding is believed to reflect memory retrieval processes …

Human hippocampal theta activity during virtual navigation

AD Ekstrom, JB Caplan, E Ho, K Shattuck, I Fried… - …, 2005 - Wiley Online Library
Abstract This study examines whether 4–8‐Hz theta oscillations can be seen in the human
hippocampus, and whether these oscillations increase during virtual movement and …