The magnitude and direction of synaptic plasticity can be determined by the precise timing of presynaptic and postsynaptic action potentials on a millisecond timescale. In vivo, however …
Cognitive alterations occur over the lifespan of every species studied and have been quantified carefully in humans, other primates and rodents. Correspondingly, changes in …
G Carlson, Y Wang, BE Alger - Nature neuroscience, 2002 - nature.com
Exogenous cannabinoids disrupt behavioral learning and impede induction of long-term potentiation (LTP) in the hippocampus, yet endogenous cannabinoids (endocannabinoids) …
The hippocampus is thought to be involved in episodic memory in humans. Place cells of the rat hippocampus offer a potentially important model system to understand episodic memory …
RD Samson, CA Barnes - European journal of neuroscience, 2013 - Wiley Online Library
Brain networks that engage the hippocampus and prefrontal cortex are central for enabling effective interactions with our environment. Some of the cognitive processes that these …
We observed sharp wave/ripples (SWR) during exploration within brief (< 2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration …
N Burgess, J O'Keefe - Current opinion in neurobiology, 2011 - Elsevier
Neuronal firing in the hippocampal formation (HF) of freely moving rodents shows striking examples of spatialorganization in the form of place, directional, boundary vector and grid …
JD Cohen, M Bolstad, AK Lee - Elife, 2017 - elifesciences.org
The hippocampus is critical for producing stable representations of familiar spaces. How these representations arise is poorly understood, largely because changes to hippocampal …
Not all areas of neuronal systems investigation have matured to the stage where computation can be understood at the microcircuit level. In mammals, insights into cortical …