IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …

Autoimmune diseases are characterized by the immune system's attack on one's own
tissues which are highly diverse and diseases differ in severity, causing damage in virtually …

The presence of autoantibodies is a defining feature of many autoimmune diseases. The
number of unique autoantibody clones is conceivably limited by immune tolerance …

Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system,
binding to and neutralizing pathogens and other foreign substances. Recent advances in …

Introduction Glycans attached to immunoglobulin G are an important regulator of chronic
systemic inflammation, one of the key drivers of aging. As people age, glycans that suppress …

Glycans play a pivotal role in biology. However, because of the low-affinity of glycan-protein
interactions, many interaction pairs remain unknown. Two important glycoproteins involved …

Immunoglobulin glycosylation is a pivotal mechanism that drives the diversification of
antibody functions. The composition of the IgG glycome is influenced by environmental …

Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

There are 2 mandatory features added sequentially en route to classical follicular lymphoma
(FL): first, the t (14; 18) translocation, which upregulates BCL2, and second, the introduction …

Since entering the stage 25 years ago as a highly specific serological biomarker for
rheumatoid arthritis, anti-citrullinated protein antibodies (ACPAs) have been a topic of …