A common underlying assumption in current drug discovery strategies is that compounds
with higher in vitro potency at their target (s) have greater potential to translate into …

Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …

We carried out a systematic evaluation of target selectivity profiles across three recent large-
scale biochemical assays of kinase inhibitors and further compared these standardized …

The identification of drug-target interactions has great significance for pharmaceutical
scientific research. Since traditional experimental methods identifying drug-target …

The goal of this study was to monitor the anti-proliferative activity of Rosmarinus officinalis
and Salvia officinalis extracts against cancer cells and to correlate this activity with their …

The present work adopted a systems pharmacology-based approach to provide new
insights into the active compounds and therapeutic targets of Bufei Yishen formula (BYF) for …

Understanding drugs and their modes of action is a fundamental challenge in systems
medicine. Key to addressing this challenge is the elucidation of drug targets, an important …

Compound Danshen Formula (CDF) is a widely used Traditional Chinese Medicine (TCM)
which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs) …

Qijian mixture, a new traditional Chinese medicine (TCM) formula comprising of Astragalus
membranaceus, Ramulus euonymi, Coptis chinensis and Pueraria lobata, was designed to …

Highlights•We now have metabolic network models; the metabolome is represented by their
nodes.•Metabolite levels are sensitive to changes in enzyme activities.•Drugs hitchhike on …