Fracture healing is a complex interplay of molecular and cellular mechanisms lasting from
days to weeks. The inflammatory phase is the first stage of fracture healing and is critical in …

Surface functionalization with bioinspired binding groups is increasingly used to steer nano-
and microscale self-assembly processes, with complementary DNA “sticky ends” as one of …

The adhesion of cell membranes is mediated by the binding of membrane-anchored
receptor and ligand proteins. In this article, we review recent results from simulations and …

Ligand-functionalized nanoparticles capable of selectively binding to diseased versus
healthy cell populations are attractive for improved efficacy of nanoparticle-based drug and …

Despite decades of progress, developing minimally invasive bone‐specific drug delivery
systems (DDS) to improve fracture healing remains a significant clinical challenge. To …

Using computer simulations, we systematically studied the influence of different design
parameters of a spherical nanoparticle tethered with monovalent ligands on its efficiency of …

Selectivity of interactions between nanoparticles functionalized by tethered ligands and cell
surfaces with different densities of receptors plays an essential role in biorecognition and its …

This Highlight Article discusses the important yet frequently overlooked entropic effects in
soft matter systems that have one or more tethered binding groups. We show that the …

The binding of streptavidin to biotin located at the terminal ends of poly (ethylene oxide)
tethered to a planar surface is studied using molecular theory. The theoretical model is …

Using Monte Carlo simulations, we analyze the efficiency in targeting mobile receptors on
cell surfaces by nanoparticles carrying multivalent (divalent, tetravalent) ligands. We show …