Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired
neuronal bioenergetics and neuroinflammation are thought to play key roles in the …

Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …