Nod-like receptor protein 3 (NLRP3), a therapeutic target that has a close relationship with
inflammatory diseases, has drawn significant attention from researchers in the field. An …

Chronic pain is not only one of the most common health problems, it is often challenging to
treat adequately. Chronic pain has a high prevalence globally, affecting approximately 20 …

RRx-001 is a shape shifting small molecule with Fast Track designation for the prevention/
amelioration of chemoradiation-induced severe oral mucositis (SOM) in newly diagnosed …

Inflammasomes are a group of protein complex located in cytoplasm and assemble in
response to a wide variety of pathogen‐associated molecule patterns, damage‐associated …

NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) receptor serves as
the central node of immune sensing in the innate immune system, and plays an important …

Nonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell
death. Cell death is significantly linked to tumor development, medication resistance, cancer …

NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition
receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns …

The current standard of care for newly diagnosed glioblastoma (GBM) is maximum surgical
resection followed by concurrent treatment with temozolomide (TMZ) and radiotherapy (RT) …

TGF-β is a central cytokine with anti-immune and anti-inflammatory activity which finds itself
at the tip or apex of the immune checkpoint 'food chain'. Immune checkpoints–which include …

Inflammatory signalling via the nod‐like receptor (NLR) family pyrin domain‐containing
protein‐3 (NLRP3) inflammasome has recently been implicated in the pathophysiology of …