Arachidonic acid metabolism plays an important role in acute ischemic syndromes affecting
the coronary or cerebrovascular territory, as reflected by biochemical measurements of …

Objectives: We investigated whether three platelet gene polymorphisms, PlA1/A2, C807T,
and C-5T Kozak (encoding, respectively, for platelet membrane glycoproteins (GP) IIIa, GP …

Background—Poor clinical outcome in aspirin-treated patients has been termed aspirin
resistance and may result from inadequate inhibition of platelet cyclooxygenase-1 (COX-1) …

Circulating platelets are heterogeneous in size and structure. Whether this translates into
differences in platelet function and efficacy of antiplatelet therapy is unclear. Hence, we …

Aspirin resistance describes a phenomenon where patients receiving aspirin therapy do not
respond favorably to treatment, and is categorized by continued incidence of adverse …

INTRODUCTION: There is wide variability in the responses of individual patients to aspirin
and clopidogrel. Polymorphisms of several platelet receptors have been related to increased …

Aspirin is one of the cornerstones of treatment for cardiovascular disease. However, some
patients may be 'resistant'to its effect: this is associated with adverse cardiovascular …

Patients who have acute coronary syndromes or are undergoing percutaneous coronary
intervention receive antiplatelet therapy to reduce the risk of atherothrombotic complications …

Mechanisms underlying the pathogenesis of ischemia/reperfusion injury are particularly
complex, multifactorial and highly interconnected. A complex and entangled interaction is …

Antiplatelet therapy is the mainstay of treatment for patients with cardiovascular disease.
However, some patients experience adverse cardiac events despite treatment with single-or …