Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM),
leading to destruction of normal kidney architecture and loss of renal function. The activation …

IgA nephropathy (IgAN) is the leading cause of kidney failure due to an incomplete
understanding of its pathogenesis. We perform single-cell RNA sequencing (RNA-seq) on …

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, resulting
in a huge socio-economic impact. Kidney is a highly complex organ and the pathogenesis …

To identify the factors mediating the progression of diabetic nephropathy (DN), we
performed RNA sequencing of kidney biopsy samples from patients with early DN …

Bulk-tissue RNA-Seq is increasingly being used in the study of physiological and
pathophysiological processes in the kidney; however, the presence of multiple cell types in …

There have been tremendous advances during the last decade in methods for large-scale,
high-throughput data generation and in novel computational approaches to analyze these …

Introduction Individuals with focal segmental glomerular sclerosis (FSGS) typically undergo
kidney biopsy only once, which limits the ability to characterize kidney cell gene expression …

Background There is a growing public concern about diabetic kidney disease (DKD), which
poses a severe threat to human health and life. It is important to discover noninvasive and …