The DNA repair system is essential for the maintenance of genome integrity and is mainly
investigated in the areas of aging and cancer. The DNA repair system is strikingly cell-type …

Lipotoxicity is the most common cause of severe kidney disease, with few treatment options
available today. Precision toxicology can improve detection of subtle intracellular changes in …

Spatial transcriptomics (ST) measures and maps transcripts within intact tissue sections,
allowing the visualization of gene activity within the spatial organization of complex …

Decades of pre-clinical research have revealed biologic pathways that have suggested
potential therapies for acute kidney injury (AKI) in experimental models. However …

The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis
in the human body. The combination of distinct, yet interrelated, molecular functions across …

Molecular assessments at the single cell level can accelerate biological research by
providing detailed assessments of cellular organization and tissue heterogeneity in both …

Newly emerging technologies are rapidly changing conventional approaches to organ
transplantation. In the modern era, the key challenges to transplantation include (1) how to …

Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality
and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with …

Methods to differentiate human pluripotent stem cells into kidney organoids were first
introduced about 5 years ago, and since that time, the field has grown substantially …

Introduction To develop effective therapies and identify novel early biomarkers for chronic
kidney disease, an understanding of the molecular mechanisms orchestrating it is essential …