Lineage tracing was originally developed by developmental biologists to identify all progeny
of a single cell during morphogenesis. More recently this approach has been applied to …

The kidney transcriptome, from single cells to whole organs... : Current Opinion in Nephrology
and Hypertension The kidney transcriptome, from single cells to whole organs and back : Current …

肾脏疾病的机制复杂, 部分原因在于肾脏组织具有大量不同的, 高度分化的细胞类型,
这为肾脏病机制研究带来困难. 传统的RNA 测序方法, 只能获得所取组织基因表达的平均水平 …

Early diagnosis and treatment are crucial for managing kidney disease, yet there remains a
need to further explore pathological mechanisms and develop minimally invasive diagnostic …

Single-cell biology is transforming the ability of researchers to understand cellular signaling
and identity across medical and biological disciplines. Especially for immune-mediated …

单细胞RNA 测序技术是生命科学领域中的革命性技术, 为动植物的细胞异质性图谱构建,
细胞谱系追踪, 免疫响应机制解析等研究提供了强有力的工具. 近年来, 单细胞RNA …

Mitophagy, the selective removal of damaged mitochondria, plays a critical role in kidney
diseases, but its involvement in hypertensive nephropathy (HTN) is not well understood. To …

Nephrotic syndrome is classically categorized by the histopathology with examples
including focal segmental glomerulosclerosis (FSGS) and minimal change disease …

Understanding the molecular mechanisms underlying mammalian kidney function requires
transcriptome profiling of the interplay between cells comprising nephron segments …

In the past few years there has been a rapid expansion of interest in the study of single cells,
especially through the new techniques that involve single-cell RNA sequencing (scRNA …