A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide

MO Marcarino, S Cicetti, MM Zanardi… - Natural Product …, 2022 - pubs.rsc.org
Covering: 2015 up to the end of 2020 Even in the golden age of NMR, the number of natural
products being incorrectly assigned is becoming larger every day. The use of quantum NMR …

Strategies for the Enhancement of Secondary Metabolite Production via Biosynthesis Gene Cluster Regulation in Aspergillus oryzae

X Jia, J Song, Y Wu, S Feng, Z Sun, Y Hu, M Yu, R Han… - Journal of Fungi, 2024 - mdpi.com
The filamentous fungus Aspergillus oryzae (A. oryzae) has been extensively used for the
biosynthesis of numerous secondary metabolites with significant applications in agriculture …

Identification of new bisabosqual-type meroterpenoids reveals non-enzymatic conversion of bisabosquals into seco-bisabosquals

MX Tong, YX Duan, YD Zhang, WY Ye… - Organic & …, 2023 - pubs.rsc.org
Bisabosqual-type meroterpenoids are fungi-derived polyketide–terpenoid hybrids bearing a
2, 3, 3a, 3a1, 9, 9a-hexahydro-1H-benzofuro [4, 3, 2-cde] chromene skeleton (6/6/6/5 ring …

A Novel Zn2Cys6 Transcription Factor, TopC, Positively Regulates Trichodin A and Asperpyridone A Biosynthesis in Tolypocladium ophioglossoides

X Liu, RQ Li, QX Zeng, YQ Li, XA Chen - Microorganisms, 2023 - mdpi.com
Asperpyridone A represents an unusual class of pyridone alkaloids with demonstrated
potential for hypoglycemic activity, primarily by promoting glucose consumption in HepG2 …

Genome Mining of α-Pyrone Natural Products from Ascidian-Derived Fungus Amphichorda felina SYSU-MS7908

S Yuan, L Chen, Q Wu, M Jiang, H Guo, Z Hu, S Chen… - Marine Drugs, 2022 - mdpi.com
Culturing ascidian-derived fungus Amphichorda felina SYSU-MS7908 under standard
laboratory conditions mainly yielded meroterpenoid, and nonribosomal peptide-type natural …

Liver-cell protective pyridones from the fungi Tolypocladium album dws120

XQ Wu, J Li, X Zhou, J Wang, YF Tan, JS Mo, S Liu… - Phytochemistry, 2023 - Elsevier
Five previously undescribed pyridone derivatives, tolypyridones I–M, were identified from
the solid rice medium fermented by Tolypocladium album dws120, along with two known …

Two New 4-Hydroxy-2-pyridone Alkaloids with Antimicrobial and Cytotoxic Activities from Arthrinium sp. GZWMJZ-606 Endophytic with Houttuynia cordata Thunb

Y Yin, D Wang, D Wu, W He, M Zuo, W Zhu, Y Xu… - Molecules, 2023 - mdpi.com
Two new 4-hydroxy-2-pyridone alkaloids furanpydone A and B (1 and 2), along with two
known compounds N-hydroxyapiosporamide (3) and apiosporamide (4) were isolated from …

Heterologous Expression of Macrollins from Phytopathogenic Macrophomina phaseolina Revealed a Cytochrome P450 Mono-oxygenase in the Biosynthesis of β …

Y Gao, M Xie, C Yu, M Zhang, J Huang… - Journal of Agricultural …, 2021 - ACS Publications
Macrophomina phaseolina (M. phaseolina) is a crucial pathogenic fungus that can cause
severe charcoal rot in economic crops and other plants. In this study, four new natural …

Base‐Promoted Synthesis of 3‐Alkenyl‐2‐pyridones from N‐Propargyl‐β‐enaminones and Aryl Aldehydes

Q Tian, S Xiao, G Cheng - Chinese Journal of Chemistry, 2021 - Wiley Online Library
Main observation and conclusion In this article, we report a base‐promoted sequential
cyclization/aldol‐type condensation/isomerization cascade reaction of N‐propargyl‐β …

Biosynthesis of Calipyridone A Represents a Fungal 2-Pyridone Formation without Ring Expansion in Aspergillus californicus

Y Guo, FJ Contesini, X Wang, S Ghidinelli… - Organic …, 2022 - ACS Publications
A chemical investigation of the filamentous fungus Aspergillus californicus led to the
isolation of a polyketide–nonribosomal peptide hybrid, calipyridone A (1). A putative …