Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options

W Löscher, H Potschka, SM Sisodiya, A Vezzani - Pharmacological reviews, 2020 - ASPET
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Serum albumin in health and disease: esterase, antioxidant, transporting and signaling properties

DA Belinskaia, PA Voronina, VI Shmurak… - International journal of …, 2021 - mdpi.com
Being one of the main proteins in the human body and many animal species, albumin plays
a decisive role in the transport of various ions—electrically neutral and charged molecules …

[HTML][HTML] Factors influencing the blood-brain barrier permeability

Y Zhao, L Gan, L Ren, Y Lin, C Ma, X Lin - Brain research, 2022 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

[HTML][HTML] Neuroinflammation microenvironment sharpens seizure circuit

B Villasana-Salazar, A Vezzani - Neurobiology of Disease, 2023 - Elsevier
A large set of inflammatory molecules and their receptors are induced in epileptogenic foci
of patients with pharmacoresistant epilepsies of structural etiologies or with refractory status …

Inflammation and oxidative stress: potential targets for improving prognosis after subarachnoid hemorrhage

F Wu, Z Liu, G Li, L Zhou, K Huang, Z Wu… - Frontiers in cellular …, 2021 - frontiersin.org
Subarachnoid hemorrhage (SAH) has a high mortality rate and causes long-term disability
in many patients, often associated with cognitive impairment. However, the pathogenesis of …

The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches

M Lévesque, G Biagini, M de Curtis… - Neuroscience & …, 2021 - Elsevier
Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

The role of astrocytes in epileptic disorders

P Hayatdavoudi, M Hosseini, V Hajali… - Physiological …, 2022 - Wiley Online Library
Epilepsy affects about 1% of the population and approximately 30% of epileptic patients are
resistant to current antiepileptic drugs. As a hallmark in epileptic tissue, many of the epileptic …

Molecular mechanisms in the genesis of seizures and epilepsy associated with viral infection

W Löscher, CL Howe - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …

Integrative role of albumin: evolutionary, biochemical and pathophysiological aspects

DA Belinskaia, PA Voronina, NV Goncharov - Journal of evolutionary …, 2021 - Springer
Being one of the main proteins in the human body and many animal species, albumin plays
a crucial role in the transport of various ions, electrically neutral molecules and in …

The adverse outcome pathway framework applied to neurological symptoms of COVID-19

HT Hogberg, A Lam, E Ohayon, MA Shahbaz… - Cells, 2022 - mdpi.com
Several reports have shown that the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has the potential to also be neurotropic. However, the mechanisms by which …