Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

Rationale: Familial recurrence studies provide strong evidence for a genetic component to
the predisposition to sporadic, nonsyndromic Tetralogy of Fallot (TOF), the most common …

In this review, we focus on two important steps in the formation of the embryonic heart:(i) the
progressive addition of late differentiating progenitor cells from the second heart field that …

The Notch signaling pathway is an ancient and highly conserved signaling pathway that
controls cell fate specification and tissue patterning in the embryo and in the adult. Region …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

The Notch pathway is a crucial cell-fate regulator in the developing heart. Attention in the
past centered on Notch function in cardiomyocytes. However, recent advances demonstrate …

Heart malformations are common congenital defects in humans. Many congenital heart
defects involve anomalies in cardiac septation or valve development, and understanding the …