Introduction Aging causes several changes in the immune system, although immune aging
is strongly influenced by individual immunological history, as well as genetic and …

Human cytomegalovirus (HCMV) is the most common cause of congenital infections and is
an important pathogen in immunocompromised individuals. Despite a robust host immune …

The immunophenotype of oldest centenarians, ie semi-and supercentenarians, could
provide important information about their ability to adapt to factors associated with immune …

Whereas the human fetal immune system is poised to generate immune tolerance and
suppress inflammation in utero, an adult-like immune system emerges to orchestrate anti …

The immune system is highly diverse, but characterization of its genetic architecture has
lagged behind the vast progress made by genome-wide association studies (GWASs) of …

Studying immune repertoire in the context of organ transplant provides important information
on how adaptive immunity may contribute and modulate graft rejection. Here we …

Immunity-related GTPase family M (IRGM), located on human chromosome 5q33. 1,
encodes a protein that promotes autophagy and suppresses the innate immune response …

Over the last several years, next-generation sequencing and its recent push toward single-
cell resolution have transformed the landscape of immunology research by revealing novel …

In this chapter we illustrate the use of some Machine Learning techniques in the context of
omics data. More precisely, we review and evaluate the use of Random Forest and …

Genetic variation contributes to immune cell function. An unprecedented analysis of genetic
associations with immune cell traits provides insights into the complex regulation of immune …