Objectives Over the past two decades, there has been tremendous growth in research
regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]) …

Empirical evidence indicates a significant bidirectional association between mental
disorders and physical diseases, but the prospective impact of mental disorders on clinical …

Importance To our knowledge, no study has previously evaluated whether individuals with
bipolar depression enriched a priori on the basis of biochemical and/or phenotypic immuno …

Individuals suffering from depressive disorders display a greater incidence of hypertension
compared with the general population, despite reports of the association between …

Cardiovascular disease and brain disorders, such as depression and cognitive dysfunction,
are highly prevalent conditions and are among the leading causes limiting patient's quality …

Bipolar disorder (BD) has been associated with immune changes, and yet their underlying
mechanisms are still not fully understood. Here, we review the current state of the field …

Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with
increased plasma levels of pro-inflammatory mediators targeting all tissues including the …

Wildfire smoke is a rapidly growing threat to global cardiovascular health. We review the
literature linking wildfire smoke exposures to cardiovascular effects. We find substantial …

Background Depression is common and burdensome in adolescents. Understanding
modifiable environmental risk factors is essential. There is evidence that physical activity is …

Importance Adverse childhood experiences (ACEs) are potentially harmful events that occur
during childhood, spanning neglect, physical or sexual abuse, parental separation, or death …