Rationale: In rodent models of depression, oxidative stress-induced reductions in NO
bioavailability contribute to impaired endothelium-dependent dilation. Endothelial …

Background E-mental healthcare is the convergence of digital technologies with mental
health services. It has been developed to fill a gap in healthcare for people who need mental …

BackgroundMood disorders, ie major depressive disorder (MDD) and bipolar disorders, are
leading sources of disability worldwide. Currently available treatments do not yield …

Major depressive and bipolar disorders predispose to atherosclerosis, and there is accruing
data from animal model, epidemiological, and genomic studies that commonly used …

Major depressive disorder (MDD) is a grave debilitating mental disease with a high
incidence and severely impairs quality of life. Therefore, its physiopathological basis study …

Background Depression and chronic pain are the two most important causes of disability
(Global Burden of Disease Study 2013). They occur together more frequently than expected …

Background Heart rate variability (HRV) has been suggested reduced in bipolar disorder
(BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV …

Objective To evaluate the efficacy and safety of lurasidone in children and adolescents with
bipolar depression. Method Patients 10 to 17 years old with a DSM-5 diagnosis of bipolar I …

Adults with bipolar disorder (BD) and major depressive disorder (MDD) have higher
circulating levels of proinflammatory cytokines than healthy controls. However, it is not …

Background In recent years, ketamine and esketamine treatment have demonstrated rapid
antidepressant effects in adults with treatment-resistant depression (TRD). Hitherto …