Autophagy is a cellular process involved in the selective degradation and recycling of
dysfunctional intracellular components. It plays a crucial role in maintaining cellular …

Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl
modifications from lysine residues in various cellular targets including histones, transcription …

Mortality in children with severe malnutrition is strongly related to signs of metabolic
dysfunction, such as hypoglycemia. Lower circulating tryptophan levels in children with …

Background The activation of NAD+-dependent deacetylase, Sirt1, by the administration of
nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases. Methods …

Sirtuins are NAD+-dependent protein deacylases involved in metabolic regulation and
aging-related diseases. Specific activators for seven human Sirtuin isoforms would be …

Diabetic mellitus (DM) is a significant public health concern worldwide with an increased
incidence of morbidity and mortality, which is particularly due to the diabetic vascular …

Abstract Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing
an important part in the pathogenesis and treatment of various disorders. They have …