It is controversial whether cells truly die via autophagy or whether—in dying cells—
autophagy is merely an innocent bystander or a well-intentioned 'Good Samaritan'trying to …

Autophagy is a conserved multistep pathway that degrades and recycles damaged
organelles and macromolecules to maintain intracellular homeostasis. The autophagy …

AKI is a common clinical condition associated with the risk of developing CKD and ESKD.
Sepsis is the leading cause of AKI in the intensive care unit (ICU) and accounts for nearly …

The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the
initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is …

The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …

Autophagy is a cellular recycling process involving self-degradation and reconstruction of
damaged organelles and proteins. Current evidence suggests that autophagy is critical in …

Alzheimer's disease (AD) is characterized by cognitive impairment in clinical presentation,
and by β-amyloid (Aβ) production and the hyper-phosphorylation of tau in basic research …

The association between chronic kidney disease (CKD) and renal cell carcinoma (RCC) is
bidirectional and multifactorial. Risk factors such as hypertension, diabetes mellitus, obesity …

Autophagy, an evolutionary conserved intracellular lysosome-dependent catabolic process,
is an important mechanism for cellular homeostasis and survival during pathologic stress …

Autophagy modulation is considered to be a promising programmed cell death mechanism
to prevent and cure a great number of disorders and diseases. The crucial step in designing …