Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …

Mendelian-randomization (MR) studies using large-scale genome-wide association studies
(GWAS) have identified causal association between educational attainment and Alzheimer's …

The folding of the human cerebral cortex is a highly genetically regulated process that
allows for a much larger surface area to fit into the cranial vault and optimizes functional …

Recent genome-wide association studies (GWASs) have revealed the polygenic nature of
psychiatric disorders and discovered a few of single-nucleotide polymorphisms (SNPs) …

Clinical and epidemiological evidence suggest that loneliness is associated with severe
mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However …

Migraine is three times more prevalent in people with bipolar disorder or depression. The
relationship between schizophrenia and migraine is less certain although glutamatergic and …

Genome-wide association studies (GWAS) have identified several common genetic variants
influencing major depression and general cognitive abilities, but little is known about …

The thalamus is a vital communication hub in the center of the brain and consists of distinct
nuclei critical for consciousness and higher-order cortical functions. Structural and functional …

Background A range of sleep disturbances are commonly experienced by patients with
psychiatric disorders, and genome-wide genetic analyses have shown some significant …