In the era of precision medicine, digital technologies and artificial intelligence, drug
discovery and development face unprecedented opportunities for product and business …

High development costs and low success rates in bringing new medicines to the market
demand more efficient and effective approaches. Identified by the FDA as a valuable …

Modeling and simulation (M&S) is a diverse discipline that uses tools from mathematics,
statistics, and computer science to arrive at quantitative predictions. Its application to …

Over the last few years the interest in diagnostic markers for specific diseases has increased
continuously. It is expected that they not only improve a patient's medical treatment but also …

Oncogenic hyperplasia is the first and inevitable stage of formation of a (solid) tumor. This
stage is also the core of many other proliferative diseases. The present work proposes the …

Two primary purposes for mathematical modeling in cell biology are (1) simulation for
making predictions of experimental outcomes and (2) parameter estimation for drawing …

Current highly active antiretroviral therapy (HAART) requires the use of combinations of
three drugs to minimize the early emergence of drug-resistant HIV strains. Therefore, long …

Today, psychological as well as physiological models of perceptual learning and decision-
making processes have recently become more biologically plausible, leading to more …

In this thesis we propose self-adaptive multi-agent systems to help decision-making in a
surveillance system. We also instantiate these systems in the context of maritime …

Biomedical systems are a complex collection of case studies where the principles of
automation and control theory are seeing increased application. This growing interest has a …