The second and third trimesters of pregnancy are crucial for the anatomical and functional
development of the gastrointestinal (GI) tract. If premature birth occurs, the immaturity of the …

Intrinsic primary afferent neurons (IPANs) of the enteric nervous system are quite different
from all other peripheral neurons. The IPANs are transducers of physiological stimuli …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Motility patterns in the mature intestine require the coordinated interaction of enteric
neurons, gastrointestinal smooth muscle, and interstitial cells of Cajal. In Hirschsprung's …

In mature animals, neurons and interstitial cells of Cajal (ICC) are essential for organized
intestinal motility. We investigated motility patterns, and the roles of neurons and myenteric …

Opinion statement Autonomic nervous system (ANS) dysfunction is common in Parkinson's
disease (PD), affects 70% to 80% of patients, and causes significant morbidity and …

Chemotherapy is the main treatment for many cancers, including colorectal cancer, a type of
cancer with some of the highest prevalence and mortality rates worldwide. Although …

Relationships of regional colonic motility to transit in health, constipation, and constipation-
predominant irritable bowel syndrome (C-IBS) are poorly characterized. This study aimed to …

The awareness is increasing that in the colon many metabolic processes take place in
relation to the fermentation of our food, which might be relevant for health and disease …

Gut motility is regulated to optimize food transport and processing. The autonomic
innervation of the gut generally includes extrinsic cranial and spinal autonomic nerves. It …