Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

Cadmium (Cd) is a known nephrotoxic heavy metal and proximal tubules are the major
target of Cd-induced acute kidney injury (AKI). We previously demonstrated that lysosomal …

Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Introduction. Obesity is one of the most important public health problems in the world.
Among obese people, there are those who, apart from excessive body weight, do not exhibit …

Abstract Coronavirus disease 2019 (COVID-19) is a current global illness triggered by
severe acute respiratory coronavirus 2 (SARS-CoV-2) leading to acute viral pneumonia …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, which will
affect more than a million people by the year 2025. However, current treatment options have …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …

Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …