Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Epigenetic changes are known to accrue in normal cells as a result of ageing and
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …

Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …

Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

Background Loss of epigenetic control is a hallmark of aging. Among the most prominent
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …