[HTML][HTML] Promising drug targets and associated therapeutic interventions in Parkinson's disease

SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

[HTML][HTML] Striatal glutamatergic hyperactivity in Parkinson's disease

F Campanelli, G Natale, G Marino, V Ghiglieri… - Neurobiology of …, 2022 - Elsevier
Glutamatergic hyperactivity in the nucleus striatum, the main basal ganglia input, has been
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced …

Animal models of Parkinson's disease: a guide to selecting the optimal model for your research

J Lama, Y Buhidma, EJR Fletcher, S Duty - Neuronal Signaling, 2021 - portlandpress.com
Parkinson's disease (PD) is a complex, multisystem disorder characterised by α-synuclein
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …

Highly sensitive and selective luminescence sensor based on two-fold interpenetrated MOFs for detecting glutamate in serum

ZH Jiao, XL Jiang, SL Hou, MH Tang… - Inorganic Chemistry, 2020 - ACS Publications
Glutamate is a biomarker for many nervous system diseases, and sensitively detecting
glutamate is meaningful in the clinic. Therefore, a unique 3D framework of Cd-MOF (1) is …

Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease: an update from the last 5 years of research

N Litim, M Morissette, T Di Paolo - Neuropharmacology, 2017 - Elsevier
Disturbance of glutamate neurotransmission in Parkinson's disease (PD) and l-DOPA
induced dyskinesia (LID) is well documented. This review focuses on advances during the …

[HTML][HTML] Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation

F Zhang, M Liu, J Tuo, L Zhang, J Zhang… - Frontiers in …, 2023 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disorder of middle-aged and
elderly people, clinically characterized by resting tremor, myotonia, reduced movement, and …

Safinamide differentially modulates in vivo glutamate and GABA release in the rat hippocampus and basal ganglia

M Morari, A Brugnoli, CA Pisanò, S Novello… - … of Pharmacology and …, 2018 - ASPET
Safinamide has been recently approved as an add-on to levodopa therapy for Parkinson
disease. In addition to inhibiting monoamine oxidase type B, it blocks sodium channels and …

New and emerging medical therapies in Parkinson's disease

M Lotia, J Jankovic - Expert opinion on pharmacotherapy, 2016 - Taylor & Francis
Introduction: Parkinson's disease (PD) is one of the most challenging neurodegenerative
disorders to treat as it manifests with a large variety of troublesome, and often disabling …

Glutamatergic neurons in the caudal zona incerta regulate parkinsonian motor symptoms in mice

LX Li, YL Li, JT Wu, JZ Song, XM Li - Neuroscience bulletin, 2022 - Springer
Parkinson's disease (PD) is the second most common and fastest-growing
neurodegenerative disorder. In recent years, it has been recognized that neurotransmitters …

Amantadine extended-release capsules for levodopa-induced dyskinesia in patients with Parkinson's disease

VD Sharma, KE Lyons, R Pahwa - Therapeutics and clinical risk …, 2018 - Taylor & Francis
Levodopa-induced dyskinesia (LID) is a common motor complication in patients with
Parkinson's disease on chronic levodopa therapy. The management of LID is important as …