[HTML][HTML] Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease
In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …
technically challenging beginnings to become common laboratory methods capable of …
A reference cell tree will serve science better than a reference cell atlas
S Domcke, J Shendure - Cell, 2023 - cell.com
Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …
[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …
types with specific spatial distribution patterns and structural and functional properties …
[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
[HTML][HTML] A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex
Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain,–. With the proliferation of multi-omics datasets …
samples of the diverse cell types in the brain,–. With the proliferation of multi-omics datasets …
[HTML][HTML] The development and evolution of inhibitory neurons in primate cerebrum
Neuroanatomists have long speculated that expanded primate brains contain an increased
morphological diversity of inhibitory neurons (INs), and recent studies have identified …
morphological diversity of inhibitory neurons (INs), and recent studies have identified …
[HTML][HTML] Cell type ontologies of the Human Cell Atlas
Massive single-cell profiling efforts have accelerated our discovery of the cellular
composition of the human body while at the same time raising the need to formalize this new …
composition of the human body while at the same time raising the need to formalize this new …
[HTML][HTML] Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation
A repeat expansion in the C9orf72 (C9) gene is the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate …
A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior
Sex hormones exert a profound influence on gendered behaviors. How individual sex
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …
[HTML][HTML] Anatomical structures, cell types and biomarkers of the Human Reference Atlas
Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …
to advance biomedical research and clinical practice. This Perspective presents …